2022 Unchained Labs Big Tuna Buffer Exchange Platform

The Unchained Labs Big Tuna provides an automated solution for buffer exchange and sample concentration in biopharmaceutical and life science research. It supports high-throughput processing using two plate formats, Unfilter 24 and Unfilter 96, facilitating parallel sample handling. Key features include:

• Ultrasonic acoustic sensor for volume measurement
• Pressure-based ultrafiltration/diafiltration (UF/DF) technology
• Supports sample volumes of 0.45–8 mL (Unfilter 24) and 100–450 µL (Unfilter 96)
• Processes various biological samples including antibodies, proteins, nucleic acids, adeno-associated viruses (AAVs), and lipid nanoparticles (LNPs)
• Achieves protein concentrations up to 200 mg/mL with a sample recovery rate of 96%
• Exchange time of approximately 4.5 hours for Unfilter 24 and 3 hours for Unfilter 96
• Operates on 100–260 VAC, 50–60 Hz electrical supply, with pressure requirements of 0.55–0.9 MPa and flow rate of 0.25 L/s
• Physical dimensions: 96 cm (L) x 81.2 cm (D) x 130 cm (H)
• Weight: 231.33 kg (510 lbs)
• The instrument offers a robust, automated workflow for efficient and reproducible biological sample preparation.